🧪 K011 — 氢医学研究

CR2Dole, Wilson, Fife (1975). Science. Hyperbaric hydrogen therapy: a possible treatment for cancer

CR3Roberts et al. (1978). Cancer Treat Rep. Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric hydrogen

CR4Abraini et al. (1994). J Appl Physiol. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture

CR6Shirahata et al. (1997). Biochem Biophys Res Commun. Electrolyzed-reduced water scavenges active oxygen species and protects DNA from oxidative damage

CR5Gharib et al. (2001). C R Acad Sci III. Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation

CR7Li et al. (2002). Cytotechnology. Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species

CR8Huang et al. (2003). Kidney Int. Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water

CR9Yanagihara et al. (2005). Biosci Biotechnol Biochem. Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding test with rats

CR1Ohsawa et al. (2007). Nat Med. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

CR98Fukuda et al. (2007). Biochem Biophys Res Commun. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress

CR17Hayashida et al. (2008). Biochem Biophys Res Commun. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury

CR226Ohsawa et al. (2008). Biochem Biophys Res Commun. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

CR236Kajiyama et al. (2008). Nutr Res. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

CR260Cai et al. (2008). Neurosci Lett. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model

CR266Saitoh et al. (2008). Oncol Res. Neutral pH hydrogen-enriched electrolyzed water achieves tumor-preferential clonal growth inhibition over normal cells and tumor invasion inhibition concurrently with intracellular oxidant repression

CR268Ye et al. (2008). Biol Pharm Bull. Inhibitory effect of electrolyzed reduced water on tumor angiogenesis

CR300Buchholz et al. (2008). Am J Transplant. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury

CR332Sato et al. (2008). Biochem Biophys Res Commun. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

CR21Sun et al. (2009). Exp Biol Med (Maywood). Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

CR26Itoh et al. (2009). Biochem Biophys Res Commun. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells

CR97Fujita et al. (2009). PLoS One. Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

CR119Fu et al. (2009). Neurosci Lett. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease

CR121Nagata et al. (2009). Neuropsychopharmacology. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice

CR143Kikkawa et al. (2009). Neuroreport. Hydrogen protects auditory hair cells from free radicals

CR159Mao et al. (2009). Biochem Biophys Res Commun. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats

CR170Zheng et al. (2009). Free Radic Res. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats

CR172Kajiya et al. (2009). Biochem Biophys Res Commun. Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

CR182Kajiya et al. (2009). Biochem Biophys Res Commun. Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis

CR195Nakashima-Kamimura et al. (2009). Cancer Chemother Pharmacol. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice

CR261Cai et al. (2009). Brain Res. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model

CR310Nakayama et al. (2009). Nephron Clin Pract. Biological effects of electrolyzed water in hemodialysis

CR30Cardinal et al. (2010). Kidney Int. Oral hydrogen water prevents chronic allograft nephropathy in rats

CR31Liu et al. (2010). Liver Int. Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice

CR99Chen et al. (2010). Neuroscience. Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model

CR114Ji et al. (2010). Brain Res. Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress

CR120Li et al. (2010). Brain Res. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress

CR122Gu et al. (2010). J Clin Biochem Nutr. Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

CR124Ueda, Nakajima, Oikawa (2010). Neurochem Res. Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium hydride

CR128Chen et al. (2010). Neurochem Res. Hydrogen-rich saline protects against spinal cord injury in rats

CR133Oharazawa et al. (2010). Invest Ophthalmol Vis Sci. Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops in retinal ischemia-reperfusion injury

CR144Taura et al. (2010). Acta Otolaryngol Suppl. Hydrogen protects vestibular hair cells from free radicals

CR155Zheng et al. (2010). Undersea Hyperb Med. Saturated hydrogen saline protects the lung against oxygen toxicity

CR157Huang et al. (2010). Crit Care. Hydrogen inhalation ameliorates ventilator-induced lung injury

CR185Chen et al. (2010). Biochem Biophys Res Commun. Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

CR189Shingu et al. (2010). J Anesth. Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury

CR196Kitamura et al. (2010). Br J Radiol. Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT

CR232Kawasaki, Guan, Tamama (2010). Biochem Biophys Res Commun. Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials

CR245Nakao et al. (2010). J Clin Biochem Nutr. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study

CR251Xie et al. (2010). Shock. Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release

CR257Xie et al. (2010). Shock. Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model

CR262Domoki et al. (2010). Pediatr Res. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs

CR270Qian et al. (2010). J Radiat Res. The potential cardioprotective effects of hydrogen in irradiated mice

CR275Qian et al. (2010). Free Radic Res. Radioprotective effect of hydrogen in cultured cells and mice

CR276Qian et al. (2010). Nucl Technol Radiat Prot. Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage

CR292Nakao et al. (2010). J Heart Lung Transplant. Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both

CR295Kawamura et al. (2010). Transplantation. Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemia/reperfusion injury in rats

CR311Nakayama et al. (2010). Nephrol Dial Transplant. A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

CR316Yan et al. (2010). Biosci Biotechnol Biochem. Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water

CR319Saitoh et al. (2010). Toxicol Ind Health. Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity and subchronic oral toxicity

CR13Qiu et al. (2011). Int Immunopharmacol. Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice

CR22Zhang et al. (2011). Int J Cardiol. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion

CR27Itoh et al. (2011). Biochem Biophys Res Commun. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages

CR32Kasuyama et al. (2011). J Clin Periodontol. Hydrogen-rich water attenuates experimental periodontitis in a rat model

CR42Sun et al. (2011). J Hepatol. The protective role of hydrogen-rich saline in experimental liver injury in mice

CR43Wang et al. (2011). Neurosci Lett. Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease

CR53Huang et al. (2011). Biochem Biophys Res Commun. Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation

CR54Song et al. (2011). Biotechnol Lett. H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells

CR55Kubota et al. (2011). Invest Ophthalmol Vis Sci. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model

CR56Ji et al. (2011). J Surg Res. The effect of hydrogen-rich saline on the brain of rats with transient ischemia

CR57Shen et al. (2011). Neurochem Res. Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest

CR88Kawamura et al. (2011). Surgery. The effect of donor treatment with hydrogen on lung allograft function in rats

CR89Buchholz et al. (2011). Transplantation. Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation

CR100Hugyecz et al. (2011). Brain Res. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus

CR101Ono et al. (2011). Med Gas Res. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study

CR102Liu et al. (2011). Med Gas Res. Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model

CR115Eckermann et al. (2011). Med Gas Res. Hydrogen is neuroprotective against surgically induced brain injury

CR126Huang et al. (2011). Brain Res. Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits

CR145Lin et al. (2011). Neurosci Lett. Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

CR156Sun et al. (2011). J Surg Res. Hydrogen-rich saline provides protection against hyperoxic lung injury

CR160Fang et al. (2011). J Burn Care Res. Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model

CR161Liu et al. (2011). J Biomed Biotechnol. Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats

CR165Hayashi et al. (2011). Am J Physiol Heart Circ Physiol. Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice

CR171Chen et al. (2011). J Surg Res. The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats

CR188Zhu et al. (2011). Nephrol Dial Transplant. Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats

CR190Wang et al. (2011). J Surg Res. Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats

CR197Matsushita et al. (2011). Jpn J Radiol. Investigation of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using blood oxygenation level-dependent magnetic resonance imaging

CR198Matsushita et al. (2011). Magn Reson Med Sci. Protective effect of hydrogen-rich water against gentamicin-induced nephrotoxicity in rats using blood oxygenation level-dependent MR imaging

CR208Yoon et al. (2011). Biol Pharm Bull. Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice

CR221Hanaoka et al. (2011). Med Gas Res. Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide

CR223Ito et al. (2011). Med Gas Res. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

CR237Kamimura et al. (2011). Obesity. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice

CR238Li et al. (2011). Cytotechnology. Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus

CR239Yu et al. (2011). Biochem Biophys Res Commun. Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage

CR246Hashimoto et al. (2011). Med Gas Res. Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat - a metabolic syndrome rat model

CR248Nakai et al. (2011). Biosci Biotechnol Biochem. Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water

CR264Yang et al. (2011). Placenta. Protective effects of hydrogen-rich saline in preeclampsia rat model

CR267Zhao et al. (2011). Int J Biol Sci. Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice

CR271Terasaki et al. (2011). Am J Physiol Lung Cell Mol Physiol. Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

CR281Kang et al. (2011). Med Gas Res. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

CR283Sun et al. (2011). Crit Care Med. Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity

CR290Yoon et al. (2011). Food Chem Toxicol. The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice

CR318Ni et al. (2011). Aviat Space Environ Med. Protective effect of hydrogen-rich saline on decompression sickness in rats

CR11Ito et al. (2012). Med Gas Res. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

CR14Xie et al. (2012). Shock. Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis

CR18Sakai et al. (2012). Scand Cardiovasc J. Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine

CR19Yoshida et al. (2012). Cardiovasc Drugs Ther. H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs

CR25Ohno et al. (2012). Oxid Med Cell Longev. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases

CR33Tanaka et al. (2012). Biochem Biophys Res Commun. Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement

CR38Liu et al. (2012). Int Immunopharmacol. The protective of hydrogen on stress-induced gastric ulceration

CR50Wei et al. (2012). Exp Eye Res. Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig

CR51Abe et al. (2012). Transplantation. Hydrogen-rich University of Wisconsin solution attenuates renal cold ischemia-reperfusion injury

CR58Qin et al. (2012). Atherosclerosis. Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS and the TNF-alpha/NF-kappaB pathway

CR59Song et al. (2012). Atherosclerosis. Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice

CR60Zheng, Yu (2012). Biochem Pharmacol. Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats

CR61Hong et al. (2012). J Neurosci Res. Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats

CR81Spulber et al. (2012). PLoS One. Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice

CR103Li et al. (2012). Brain Res. Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines

CR104Nagatani et al. (2012). Shock. Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia

CR105Ge et al. (2012). Neurol Res. Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress

CR111Zhuang et al. (2012). BMC Neurosci. Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits

CR112Zhan et al. (2012). Crit Care Med. Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats

CR116Hou et al. (2012). Brain Res Bull. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury

CR117Ji et al. (2012). J Surg Res. Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress

CR135Xiao et al. (2012). J Ocul Pharmacol Ther. Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model

CR137Huang et al. (2012). Ophthalmic Res. Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression

CR138Feng et al. (2012). Int J Ophthalmol. Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats

CR146Zhou et al. (2012). Neuroscience. Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs

CR149Qu et al. (2012). Int J Pediatr Otorhinolaryngol. Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress

CR151Qu et al. (2012). Acta Pharmacol Sin. Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils

CR153Shi et al. (2012). Heart Lung Circ. Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats

CR154Li et al. (2012). J Surg Res. Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits

CR167Yu, Zheng (2012). Mol Cell Biochem. Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats

CR176Nishimura et al. (2012). Br J Nutr. Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats

CR180Kawai et al. (2012). Hepatology. Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice

CR181Xiang et al. (2012). World J Gastroenterol. Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine

CR186Ren et al. (2012). J Trauma Acute Care Surg. Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats

CR199Katakura et al. (2012). Med Gas Res. Hydrogen-rich water inhibits glucose and alpha,beta -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney

CR202Lee et al. (2012). J Pediatr Surg. Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats

CR203Jiang et al. (2012). J Urol. Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats

CR209Guo et al. (2012). J Biomed Res. Hydrogen-rich saline protects against ultraviolet B radiation injury in rats

CR210Kato et al. (2012). J Photochem Photobiol B. Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes

CR212Ono et al. (2012). Med Gas Res. Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers

CR218Ishibashi et al. (2012). Med Gas Res. Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

CR224Aoki et al. (2012). Med Gas Res. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

CR227Ekuni et al. (2012). Arch Oral Biol. Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model

CR229Sun et al. (2012). Cardiovasc Res. Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats

CR234Takeuchi et al. (2012). Intern Med. Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study

CR235Kato et al. (2012). J Nanosci Nanotechnol. Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood fluidity

CR240Wang et al. (2012). Chin Med J (Engl). Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress

CR242Zong et al. (2012). Metabolism. Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters

CR249Ostojic (2012). Mayo Clin Proc. Serum alkalinization and hydrogen-rich water in healthy men

CR252Zhou et al. (2012). J Surg Res. Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture

CR253Xie et al. (2012). Shock. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis

CR258Xu et al. (2012). J Inflamm (Lond). Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema

CR277Chuai et al. (2012). Biochem J. Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals

CR278Yang et al. (2012). Med Sci Monit. Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis

CR279Chuai et al. (2012). Med Sci Monit. Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice

CR284Wang et al. (2012). Neurol Res. Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning

CR294Noda et al. (2012). Transpl Int. Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated deterioration

CR321Xie et al. (2012). PLoS One. H(2) enhances arabidopsis salt tolerance by manipulating ZAT10/12-mediated antioxidant defence and controlling sodium exclusion

CR333Ono et al. (2012). Med Gas Res. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level

CR334Seo, Kurokawa, Sato (2012). Med Gas Res. A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum

CR335Shimouchi et al. (2012). Adv Exp Med Biol. Estimation of molecular hydrogen consumption in the human whole body after the ingestion of hydrogen-rich water

CR10Huang et al. (2013). Resuscitation. The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest

CR20Shinbo et al. (2013). Am J Physiol Heart Circ Physiol. Breathing nitric oxide plus hydrogen gas reduces ischemia-reperfusion injury and nitrotyrosine production in murine heart

CR28Manaenko et al. (2013). Crit Care Med. Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice

CR29Chen et al. (2013). Int J Mol Med. Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways

CR34Sun et al. (2013). Osteoporos Int. Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats

CR35Xu, Zhang (2013). Physiol Res. Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats

CR39Chen et al. (2013). Can J Neurol Sci. Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress

CR44Iio et al. (2013). Med Gas Res. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells

CR45Shin et al. (2013). PLoS One. Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo

CR52Noda et al. (2013). J Heart Lung Transplant. A novel method of preserving cardiac grafts using a hydrogen-rich water bath

CR62Guo et al. (2013). Br J Pharmacol. Hydrogen water consumption prevents osteopenia in ovariectomized rats

CR63Xiao et al. (2013). Eur Rev Med Pharmacol Sci. Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma

CR64Liu et al. (2013). Int J Ophthalmol. Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells

CR65Li et al. (2013). Food Chem Toxicol. Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats

CR66Zhuang et al. (2013). J Neurosci Res. Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits

CR82Kawamura et al. (2013). Am J Physiol Lung Cell Mol Physiol. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo

CR83Zhai et al. (2013). Free Radic Biol Med. Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression

CR90Chen et al. (2013). Int J Surg. Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages

CR95Matsumoto et al. (2013). Sci Rep. Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

CR96Yoritaka et al. (2013). Mov Disord. Pilot study of H(2) therapy in Parkinson’s disease: a randomized double-blind placebo-controlled trial

CR106Nagatani et al. (2013). Med Gas Res. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies

CR107Olah et al. (2013). Neonatology. Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs

CR127Zhou et al. (2013). Brain Res. Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits

CR136Feng et al. (2013). Curr Eye Res. Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats

CR139Tian et al. (2013). Med Gas Res. Hydrogen-rich saline ameliorates the retina against light-induced damage in rats

CR142Yang, Yan, Ding (2013). Mol Vis. Hydrogen saline prevents selenite-induced cataract in rats

CR163Ning et al. (2013). PLoS One. Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats

CR164He et al. (2013). Mol Biol Rep. Protection of oral hydrogen water as an antioxidant on pulmonary hypertension

CR173He et al. (2013). J Surg Res. Protective effects of hydrogen-rich saline on ulcerative colitis rat model

CR174Chen et al. (2013). Dig Dis Sci. Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing hydrogen production

CR175Sheng et al. (2013). J Pediatr Surg. Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats

CR179Xia et al. (2013). Clin Transl Sci. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B

CR187Zhang, Feng, Chen (2013). Evid Based Complement Alternat Med. Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat

CR191Xu et al. (2013). Int Immunopharmacol. Hydrogen-rich saline ameliorates renal injury induced by unilateral ureteral obstruction in rats

CR201Matsumoto, Ueda, Kakizaki (2013). Urology. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome

CR204Fan et al. (2013). J Urol. Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model

CR207Zhao et al. (2013). J Zhejiang Univ Sci B. Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

CR211Ignacio et al. (2013). Mol Cell Toxicol. The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice

CR213Ignacio et al. (2013). Evid Based Complement Alternat Med. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice

CR216Li et al. (2013). Med Gas Res. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro

CR217Yu et al. (2013). J Asian Earth Sci. Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes

CR220Cai et al. (2013). Mol Cell Biochem. Treatment with hydrogen molecule alleviates TNFalpha-induced cell injury in osteoblast

CR228Jiang et al. (2013). Int J Mol Med. Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis

CR231Zhao et al. (2013). Cell Physiol Biochem. Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo

CR241Amitani et al. (2013). PLoS One. Hydrogen improves glycemic control in type1 diabetic animal model by promoting glucose uptake into skeletal muscle

CR243Song et al. (2013). J Lipid Res. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome

CR247Nishimura et al. (2013). J Nutr. Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats

CR254Li et al. (2013). J Surg Res. Effects of hydrogen-rich saline treatment on polymicrobial sepsis

CR255Liu et al. (2013). World J Gastroenterol. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury

CR259Fujii et al. (2013). Artif Organs. Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model

CR272Jiang et al. (2013). Basic Clin Pharmacol Toxicol. Protection by hydrogen against gamma ray-induced testicular damage in rats

CR280Yang et al. (2013). Int J Radiat Biol. Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation

CR285Shen et al. (2013). CNS Neurosci Ther. Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning

CR286Wang et al. (2013). J Emerg Med. Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning

CR287Yonamine et al. (2013). Anesthesiology. Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice

CR293Tan et al. (2013). Int J Cardiol. Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia

CR296Zhou et al. (2013). J Heart Lung Transplant. Hydrogen inhalation decreases lung graft injury in brain-dead donor rats

CR304Qian et al. (2013). Transplantation. Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD)

CR314Terawaki et al. (2013). Med Gas Res. Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity

CR322Xu et al. (2013). Plant Soil. Hydrogen-rich water alleviates salt stress in rice during seed germination

CR327Zeng, Zhang, Sun (2013). PLoS One. Molecular hydrogen is involved in phytohormone signaling and stress responses in plants

CR328Jin et al. (2013). Plant Cell Environ. Hydrogen gas acts as a novel bioactive molecule in enhancing plant tolerance to paraquat-induced oxidative stress via the modulation of heme oxygenase-1 signalling system

CR329Cui et al. (2013). J Hazard Mater. Alleviation of cadmium toxicity in Medicago sativa by hydrogen-rich water

CR336Shimouchi et al. (2013). Adv Exp Med Biol. Molecular hydrogen consumption in the human body during the inhalation of hydrogen gas

CR36Li et al. (2014). J Bone Miner Metab. Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells

CR48Hong et al. (2014). PLoS One. Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway

CR67Tan et al. (2014). Clin Res Hepatol Gastroenterol. Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats

CR68Zhang et al. (2014). Int Immunopharmacol. Effect of hydrogen-rich water on acute peritonitis of rat models

CR69Xin et al. (2014). Mol Cell Biochem. Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats

CR76Ren et al. (2014). Mediators Inflamm. Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice

CR77Liu et al. (2014). CNS Neurosci Ther. Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord injury in rats

CR79Zhang et al. (2014). Brain Res Bull. Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats

CR84Xie et al. (2014). Mol Med Rep. Hydrogen gas protects against serum and glucose deprivationinduced myocardial injury in H9c2 cells through activation of the NFE2related factor 2/heme oxygenase 1 signaling pathway

CR91Lin et al. (2014). J Plant Physiol. Hydrogen-rich water regulates cucumber adventitious root development in a heme oxygenase-1/carbon monoxide-dependent manner

CR108Cui et al. (2014). J Surg Res. Hydrogen-rich saline attenuates neuronal ischemia--reperfusion injury by protecting mitochondrial function in rats

CR113Takeuchi et al. (2014). BMC Neurol. Effects of intravenous infusion of hydrogen-rich fluid combined with intra-cisternal infusion of magnesium sulfate in severe aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial

CR118Dohi et al. (2014). PLoS One. Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury

CR123Liu et al. (2014). Brain Res. Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

CR125Kashiwagi et al. (2014). Oxid Med Cell Longev. Electrochemically reduced water protects neural cells from oxidative damage

CR129Ge et al. (2014). PLoS One. Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats

CR130Kawaguchi et al. (2014). PLoS One. Molecular hydrogen attenuates neuropathic pain in mice

CR131Zhang et al. (2014). Neuroscience. Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats

CR141Sun et al. (2014). PLoS One. Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush

CR147Chen et al. (2014). PLoS One. Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect

CR148Kurioka et al. (2014). Neurosci Res. Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species

CR150Kikkawa et al. (2014). Neurosci Lett. Hydrogen protects auditory hair cells from cisplatin-induced free radicals

CR152Tomofuji et al. (2014). Sci Rep. Effects of hydrogen-rich water on aging periodontal tissues in rats

CR166Kato et al. (2014). Am J Physiol Heart Circ Physiol. Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters

CR168Zhang et al. (2014). World J Gastroenterol. Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats

CR169Xue et al. (2014). BMC Complement Altern Med. Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

CR177Liu et al. (2014). BMC Gastroenterol. Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release

CR178Matsuno et al. (2014). Transplant Proc. Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass

CR184Koyama et al. (2014). Hepatol Res. Effects of oral intake of hydrogen water on liver fibrogenesis in mice

CR192Gu et al. (2014). J Surg Res. Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats

CR193Liu et al. (2014). Int J Clin Exp Med. A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats

CR205Li et al. (2014). J Assist Reprod Genet. Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice

CR214Yoon et al. (2014). Biol Pharm Bull. Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

CR219Ishibashi et al. (2014). Int Immunopharmacol. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study

CR225Ostojic et al. (2014). Postgrad Med. Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries

CR230Sakai et al. (2014). Vasc Health Risk Manag. Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function

CR250Ostojic, Stojanovic (2014). Res Sports Med. Hydrogen-rich water affected blood alkalinity in physically active men

CR263Mano et al. (2014). Free Radic Biol Med. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion

CR273Mei et al. (2014). J Dermatolog Treat. Hydrogen protects rats from dermatitis caused by local radiation

CR274Watanabe et al. (2014). J Radiat Res. Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats

CR282Zhao et al. (2014). J Cell Mol Med. Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction

CR288Takaenoki et al. (2014). Anesthesiology. Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood

CR289Wu et al. (2014). Pharmazie. Hydrogen-containing saline attenuates doxorubicin-induced heart failure in rats

CR291Wang et al. (2014). Toxicol Appl Pharmacol. Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats

CR297Noda et al. (2014). Transplantation. Hydrogen preconditioning during ex vivo lung perfusion improves the quality of lung grafts in rats

CR303Yamada et al. (2014). ScientificWorldJournal. Hydrogen supplementation of preservation solution improves viability of osteochondral grafts

CR306Hayashida et al. (2014). Circulation. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management

CR307Huo et al. (2014). Anesth Analg. Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and cardiopulmonary resuscitation in rats

CR308Du et al. (2014). Exp Ther Med. Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock

CR312Terawaki et al. (2014). Hemodial Int. Effect of a hydrogen (H2)-enriched solution on the albumin redox of hemodialysis patients

CR320Chen et al. (2014). J Hazard Mater. Hydrogen-rich water alleviates aluminum-induced inhibition of root elongation in alfalfa via decreasing nitric oxide production

CR323Hu et al. (2014). Food Chem. Hydrogen-rich water delays postharvest ripening and senescence of kiwifruit

CR324Xie et al. (2014). Plant Physiol. Reactive Oxygen Species-Dependent Nitric Oxide Production Contributes to Hydrogen-Promoted Stomatal Closure in Arabidopsis

CR325Su et al. (2014). J Agric Food Chem. Hydrogen-rich water reestablishes ROS homeostasis but exerts differential effects on anthocyanin synthesis in two varieties of radish sprouts under UV-A irradiation

CR331Cui et al. (2014). Ecotoxicol Environ Saf. Hydrogen-rich water confers plant tolerance to mercury toxicity in alfalfa seedlings

CR337Liu et al. (2014). Sci Rep. Estimation of the hydrogen concentration in rat tissue using an airtight tube following the administration of hydrogen via various routes

CR338Penders, Kissner, Koppenol (2014). Free Radic Biol Med. ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite

CR12Sobue et al. (2015). Mol Cell Biochem. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents

CR15Hattori et al. (2015). Free Radic Res. Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury

CR16Zhang, Liu, Zhang (2015). J Surg Res. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction

CR23Jing et al. (2015). Heart Lung Circ. Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats

CR24Zhang et al. (2015). Sci Rep. Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats

CR37Guo et al. (2015). J Transl Med. Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation

CR40Wu et al. (2015). Cardiovasc Pathol. Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice

CR41Zhai et al. (2015). Exp Mol Pathol. Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats

CR46Liu et al. (2015). J Plast Reconstr Aesthet Surg. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway

CR47Zhang et al. (2015). World J Gastroenterol. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice

CR49Guo et al. (2015). PLoS One. Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats

CR70Wang et al. (2015). Burns. Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation

CR71Zhang et al. (2015). Exp Ther Med. Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappaB signaling pathway

CR72Shi et al. (2015). Mediators Inflamm. Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-kappaB pathway

CR74Chen et al. (2015). Oxid Med Cell Longev. Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury

CR75Kohama et al. (2015). Surgery. Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and resuscitation

CR78Kishimoto et al. (2015). J Thorac Cardiovasc Surg. Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects

CR80Xie et al. (2015). Shock. Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and Vascular Endothelial Permeability via Rho-Associated Coiled-Coil Protein Kinase

CR85Song et al. (2015). Free Radic Biol Med. Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout mice

CR86Li et al. (2015). J Surg Res. Hydrogen gas inhibits high-mobility group box 1 release in septic mice by upregulation of heme oxygenase 1

CR87Li et al. (2015). Shock. Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1

CR92Chen et al. (2015). Inflammation. H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain

CR93Yu et al. (2015). J Surg Res. Lactulose accelerates liver regeneration in rats by inducing hydrogen

CR94Wei et al. (2015). Cell Physiol Biochem. Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress

CR109Han et al. (2015). Brain Res. Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins

CR110Takeuchi et al. (2015). BMC Neurosci. Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

CR132Shu et al. (2015). Anesthesiology. Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats

CR134Liu et al. (2015). Mol Med Rep. Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion injury

CR140Yokota et al. (2015). Clin Experiment Ophthalmol. Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina

CR158Liu et al. (2015). Shock. Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury

CR162Sato et al. (2015). Kitasato Med J. Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice

CR183Lee et al. (2015). Hepatol Res. Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats

CR200Peng et al. (2015). Int J Clin Exp Pathol. Inhalation of hydrogen gas ameliorates glyoxylate-induced calcium oxalate deposition and renal oxidative stress in mice

CR206Chen, Jiang (2015). Int J Clin Exp Med. Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke

CR215Ishibashi et al. (2015). Mol Med Rep. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases

CR222Huang et al. (2015). J Surg Res. Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle

CR233Tanikawa et al. (2015). Hirosaki Medical Journal. Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population

CR244Song et al. (2015). J Clin Endocrinol Metab. Hydrogen activates ATP-binding cassette transporter A1-dependent efflux ex vivo and improves high-density lipoprotein function in patients with hypercholesterolemia: a double-blinded, randomized and placebo-controlled trial

CR256Yu et al. (2015). Genet Mol Res. Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin

CR265Guan et al. (2015). Arch Gynecol Obstet. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells

CR269Runtuwene et al. (2015). PeerJ. Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer

CR298Haam et al. (2015). Eur J Cardiothorac Surg. The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger

CR299Liu et al. (2015). Exp Biol Med (Maywood). Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats

CR301Shigeta et al. (2015). Transplantation. Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats

CR302Luo et al. (2015). Mediators Inflamm. Hydrogen-rich saline protects against ischemia/reperfusion injury in grafts after pancreas transplantations by reducing oxidative stress in rats

CR305Yuan et al. (2015). Med Sci Monit. Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation

CR309Du et al. (2015). J Surg Res. Effects of three hydrogen-rich liquids on hemorrhagic shock in rats

CR313Tange, Takesawa, Yoshitake (2015). Nephrourol Mon. Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin

CR315Terawaki et al. (2015). Perit Dial Int. Successful treatment of encapsulating peritoneal sclerosis by hemodialysis and peritoneal lavage using dialysate containing dissolved hydrogen

CR317Nakata et al. (2015). Med Gas Res. Stimulation of human damaged sperm motility with hydrogen molecule

CR326Zhang et al. (2015). Plant Growth Regul. Protective effects of hydrogen-rich water on the photosynthetic apparatus of maize seedlings (Zea mays L.) as a result of an increase in antioxidant enzyme activities under high light stress

CR330Wu et al. (2015). J Plant Physiol. Hydrogen-rich water enhances cadmium tolerance in Chinese cabbage by reducing cadmium uptake and increasing antioxidant capacities

CR339Kato, Matsuoka, Miwa (2015). Mater Sci Eng C Mater Biol Appl. Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2′-bipyridyl methods

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